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    Bootstrapping our way to an ageless future
by   Aubrey de Grey

Biomedical gerontologist Aubrey de Grey expects many people alive today to live to 1000 years of age and to avoid age-related health problems even at that age. In this excerpt from his just-published, much-awaited book, Ending Aging, he explains how.


Originally published in Ending Aging, St. Martin's Press, Sept. 2007, Chapter 14. Published on KurzweilAI.net Sept. 19, 2007.

Bootstrapping our way to an ageless future

I have a confession to make. In Chapters 5 through 12, where I explained the details of SENS, I elided one rather important fact—a fact that the biologists among my audience will very probably have spotted. I'm going to address that omission in this chapter, building on a line of reasoning that I introduced in an ostensibly quite circumscribed context towards the end of Chapter 9.

It is this: the therapies that we develop in a decade or so in mice, and those that may come only a decade or two later for humans, will not be perfect. Other things being equal, there will be a residual accumulation of damage within our bodies, however frequently and thoroughly we apply these therapies, and we will eventually experience age-related decline and death just as now, only at a greater age. Probably not all that much greater either — probably only 30-50 years older than today.

But other things won't be equal. In this chapter, I'm going to explain why not—and why, as you may already know from other sources, I expect many people alive today to live to 1000 years of age and to avoid age-related health problems even at that age.

I'll start by describing why it's unrealistic to expect these therapies to be perfect.

Evolution didn't leave notes

I emphasised in Chapter 3 that the body is a machine, and that that's both why it ages and why it can in principle be maintained. I made a comparison with vintage cars, which are kept fully functional even 100 years after they were built, using the same maintenance technologies that kept them going 50 years ago when they were already far older than they were ever designed to be. More complex machines can also be kept going indefinitely, though the expense and expertise involved may mean that this never happens in practice because replacing the machine is a reasonable alternative. This sounds very much like a reason to suppose that the therapies we develop to stave off aging for a few decades will indeed be enough to stave it off indefinitely.

But actually that's overoptimistic. All we can reliably infer from a comparison with man-made machines is that a truly comprehensive panel of therapies, which truly repairs everything that goes wrong with us as a result of aging, is possible in principle— not that it is foreseeable. And in fact, if we look back at the therapies I've described in this book, we can see that actually one thing about them is very unlike maintenance of a man-made machine: these therapies strive to minimally alter metabolism itself, and target only the initially inert side-effects of metabolism, whereas machine maintenance may involve adding extra things to the machinery itself (to the fuel or the oil of a car, for example). We can get away with this sort of invasive maintenance of man-made machines because we (well, some of us!) know how they work right down to the last detail, so we can be adequately sure that our intervention won't have unforeseen side-effects. With the body—even the body of a mouse—we are still profoundly ignorant of the details, so we have to sidestep our ignorance by interfering as little as possible.

What that means for efficacy of therapies is that, as we fix more and more aspects of aging, you can bet that new aspects will be unmasked. These new things—eighth and subsequent items to add to the "seven deadly things" listed in this book—will not be fatal at a currently normal age, because if they were, we'd know about them already. But they'll be fatal eventually, unless we work out how to fix them too.

It's not just "eighth things" we have to worry about, either. Within each of the seven existing categories, there are some subcategories that will be easier to fix than others. For example, there are lots of chemically distinct cross-links responsible for stiffening our arteries; some of them may be broken with ALT-711 and related molecules, but others will surely need more sophisticated agents that have not yet been developed. Another example: obviating mitochondrial DNA by putting modified copies of it into the cell's chromosomes requires gene therapy, and thus far we have no gene therapy delivery system ("vector") that can safely get into all cells, so for the foreseeable future we'll probably only be able to protect a subset of cells from mtDNA mutations. Much better vectors will be needed if we are to reach all cells.

In practice, therefore, therapies that rejuvenate 60-year-olds by 20 years will not work so well the second time around. When the therapies are applied for the first time, the people receiving them will have 60 years of "easy" damage (the types that the therapies can remove) and also 60 years of "difficult" damage. But by the time beneficiaries of these therapies have returned to biologically 60 (which, let's presume, will happen when they're chronologically about 80), the damage their bodies contain will consist of 20 years of "easy" damage and 80 years of "difficult" damage. Thus, the therapies will only rejuvenate them by a much smaller amount, say ten years. So they'll have to come back sooner for the third treatment, but that will benefit them even less… and very soon, just like Achilles catching up with the tortoise in Zeno's paradox, aging will get the better of them. See Figure 1.

Figure 1

Figure 1. The diminishing returns delivered by repeated application of a rejuvenation regime.

Back in Chapters 3 and 4 I explained that, contrary to one's intuition, rejuvenation may actually be easier than retardation. Now it's time to introduce an even more counterintuitive fact: that, even though it will be much harder to double a middle-aged human's remaining lifespan than a middle-aged mouse's, multiplying that remaining lifespan by much larger factors—ten or 30, say—will be much easier in humans than in mice.

The two-speed pace of technology

I'm now going to switch briefly from science to the history of science, or more precisely the history of technology.

It was well before recorded history that people began to take an interest in the possibility of flying: indeed, this may be a desire almost as ancient as the desire to live forever. Yet, with the notable but sadly unreproduced exception of Daedalus and Icarus, no success in this area was achieved until about a century ago. (If we count balloons then we must double that, but really only airships—balloons that can control their direction of travel reasonably well—should be counted, and they only emerged at around the same time as the aircraft.) Throughout the previous few centuries, engineers from Leonardo on devised ways to achieve controlled powered flight, and we must presume that they believed their designs to be only a few decades (at most) from realisation. But they were wrong.

Ever since the Wright brothers flew at Kitty Hawk, however, things have been curiously different. Having mastered the basics, aviation engineers seem to have progressed to ever greater heights (literally as well as metaphorically!) at an almost serenely smooth pace. To pick a representative selection of milestones: Lindbergh flew the Atlantic 24 years after the first powered flight occurred, the first commercial jetliner (the Comet) debuted 22 years after that, and the first supersonic airliner (Concorde) followed after a further 20 years.

This stark contrast between fundamental breakthroughs and incremental refinements of those breakthroughs is, I would contend, typical of the history of technological fields. Further, I would argue that it's not surprising: both psychologically and scientifically, bigger advances are harder to estimate the difficulty of.

I mention all this, of course, because of what it tells us about the likely future progress of life extension therapies. Just as people were wrong for centuries about how hard it as to fly but eventually cracked it, we've been wrong since time immemorial about how hard aging is to combat but we'll eventually crack it too. But just as people have been pretty reliably correct about how to make better and better aircraft once they had the first one, we can expect to be pretty reliably correct about how to repair the damage of aging more and more comprehensively once we can do it a little.

That's not to say it'll be easy, though. It'll take time, just as it took time to get from the Wright Flyer to Concorde. And that is why, if you want to live to 1000, you can count yourself lucky that you're a human and not a mouse. Let me take you through the scenario, step by step.

Suppose we develop Robust Mouse Rejuvenation in 2016, and we take a few dozen two-year-old mice and duly treble their one-year remaining lifespans. That will mean that, rather than dying in 2017 as they otherwise would, they'll die in 2019. Well, maybe not—in particular, not if we can develop better therapies by 2018 that re-treble their remaining lifespan (which will by now be down to one year again). But remember, they'll be harder to repair the second time: their overall damage level may be the same as before they received the first therapies, but a higher proportion of that damage will be of types that those first therapies can't fix. So we'll only be able to achieve that re-trebling if the therapies we have available by 2018 are considerably more powerful than those that we had in 2016. And to be honest, the chance that we'll improve the relevant therapies that much in only two years is really pretty slim. In fact, the likely amount of progress in just two years is so small that it might as well be considered zero. Thus, our murine heroes will indeed die in 2019 (or 2020 at best), despite our best efforts.

But now, suppose we develop Robust Human Rejuvenation in 2031, and we take a few dozen 60-year-old humans and duly double their 30-year remaining lifespans. By the time they come back in (say) 2051, biologically 60 again but chronologically 80, they'll need better therapies, just as the mice did in 2018. But luckily for them, we'll have had not two but twenty years to improve the therapies. And 20 years is a very respectable period of time in technology—long enough, in fact, that we will with very high probability have succeeded in developing sufficient improvements to the 2031 therapies so that those 80-year-olds can indeed be restored from biologically 60 to biologically 40, or even a little younger, despite their enrichment (relative to 2031) in harder-to-repair types of damage. So unlike the mice, these humans will have just as many years (20 or more) of youth before they need third-generation treatments as they did before the second.

And so on …. See Figure 2.

Figure 2

Figure 2. How the diminishing returns depicted in Figure 1 are avoided by repeated application of a rejuvenation regime that is sufficiently more effective each time than the previous time.

Longevity Escape Velocity

The key conclusion of the logic I've set out above is that there is a threshold rate of biomedical progress that will allow us to stave off aging indefinitely, and that that rate is implausible for mice but entirely plausible for humans. If we can make rejuvenation therapies work well enough to give us time to make then work better, that will give us enough additional time to make them work better still, which will … you get the idea. This will allow us to escape age-related decline indefinitely, however old we become in purely chronological terms. I think the term "longevity escape velocity" (LEV) sums that up pretty well.1

One feature of LEV that's worth pointing out is that we can accumulate lead-time. What I mean is that if we have a period in which we improve the therapies faster than we need to, that will allow us to have a subsequent period in which we don't improve them so fast. It's only the average rate of improvement, starting from the arrival of the first therapies that give us just 20 or 30 extra years, that needs to stay above the LEV threshold.

In case you're having trouble assimilating all this, let me describe it in terms of the physical state of the body. Throughout this book, I've been discussing aging as the accumulation of molecular and cellular "damage" of various types, and I've highlighted the fact that a modest quantity of damage is no problem—metabolism just works around it, in the same way that a household only needs to put out the garbage once a week, not every hour. In those terms, the attainment and maintenance of escape velocity simply means that our best therapies must improve fast enough to outweigh the progressive shift in the composition of our aging damage to more repair-resistant forms, as the forms that are easier to repair are progressively eliminated by our therapies. If we can do this, the total amount of damage in each category can be kept permanently below the level that initiates functional decline.

Another, perhaps simpler, way of looking at this is to consider the analogy with literal escape velocity, i.e. the overcoming of gravity. Suppose you're at the top of a cliff and you jump off. Your remaining life expectancy is short—and it gets shorter as you descend to the rocks below. This is exactly the same as with aging: the older you get, the less remaining time you can expect to live. The situation with the periodic arrival of ever better rejuvenation therapies is then a bit like jumping off a cliff with a jet-pack on your back. Initially the jetpack is turned off, but as you fall, you turn it on and it gives you a boost, slowing your fall. As you fall further, you turn up the power on the jetpack, and eventually you start to pull out of the dive and even start shooting upwards. And the further up you go, the easier it is to go even further.

The political and social significance of discussing LEV

I've had a fairly difficult time convincing my colleagues in biogerontology of the feasibility of the various SENS components, but in general I've been successful once I've been given enough time to go through the details. When it comes to LEV, on the other hand, the reception to my proposals can best be described as blank incomprehension. This is not too surprising, in hindsight, because the LEV concept is even further distant from the sort of scientific thinking that my colleagues normally do than my other ideas are: it's not only an area of science that's distant from mainstream gerontology, it's not even science at all in the strict sense, but rather the history of technology. But I regard that as no excuse. The fact is, the history of technology is evidence, just like any other evidence, and scientists have no right to ignore it.

Another big reason for my colleagues' resistance to the LEV concept is, of course, that if I'm seen to be right that achievement of LEV is foreseeable, they can no longer go around saying that they're working on postponing aging by a decade or two but no more. As I outlined in Chapter 13, there is an intense fear within the senior gerontology community of being seen as having anything to do with radical life extension, with all the uncertainties that it will surely herald. They want nothing to do with such talk.
You might think that my reaction to this would be to focus on the short term: to avoid antagonising my colleagues with the LEV concept and its implications of four-digit lifespans, in favour of increased emphasis on the fine details of getting the SENS strands to work in a first-generation form. But this is not an option for me, for one very simple and incontrovertible reason: I'm in this business to save lives. In order to maximise the number of lives saved—healthy years added to people's lives, if you'd prefer a more precise measure—I need to address the whole picture. And that means ensuring that you, dear reader—the general public—appreciate the importance of this work enough to motivate its funding.

Now, your first thought may be: hang on, if indefinite life extension is so unpalatable, wouldn't funding be attracted more easily by keeping quiet about it? Well, no—and for a pretty good reason.

The world's richest man, Bill Gates, set up a foundation a few years ago whose primary mission is to address health issues in the developing world.2 This is a massively valuable humanitarian effort, which I wholeheartedly support, even though it doesn't directly help SENS at all. I'm not the only person who supports it, either: in 2006 the world's second richest man, Warren Buffett, committed a large proportion of his fortune to be donated in annual increments to the Gates Foundation.3

The eagerness of extremely wealthy individuals to contribute to world health is, in more general terms, an enormous boost for SENS. This is mainly because a rising tide raises all boats: once it has become acceptable (even meritorious) among that community to be seen as a large-scale health philanthropist, those with "only" a billion or two to their name will be keener to join the trend than if it is seen as a crazy way to spend your hard-earned money.

But there's a catch. That logic only works if the moral status of SENS is seen to compare with that of the efforts that are now being funded so well. And that's where LEV makes all the difference.

SENS therapies will be expensive to develop and expensive to administer, at least at first. Let's consider how the prospect of spending all that money might be received if the ultimate benefit would be only to add a couple of decades to the lives of people who are already living longer than most in the developing world, after which those people would suffer the same duration of functional decline that they do now.

It's not exactly the world's most morally imperative action, is it?

Indeed, I would go so far as to say that, if I were in control of a few billion dollars, I would be quite hesitant to spend it on such a marginal improvement in the overall quality and quantity of life of those who are already doing better in that respect than most, when the alternative exists of making a similar or greater improvement to the quality and quantity of life of the world's less fortunate inhabitants.

The LEV concept doesn't make much difference in the short term to who would benefit from these therapies, of course: it will necessarily be those who currently die of aging, so in the first instance it will predominantly be those in wealthy nations. But there is a very widespread appreciation in the industrialised world—an appreciation that, I feel, extends to the wealthy sectors of society—that progress in the long term relies on aiming high, and in particular that the moral imperative to help those at the rear of the field to catch up is balanced by the moral imperative to maximise the average rate of progress across the whole population, which initially means helping those who are already ahead. The fact that SENS is likely to lead to LEV means that developing SENS gives a huge boost to the quality and quantity of life of whomever receives it: so huge, in fact, that there is no problem justifying it in comparison the alternative uses to which a similar sum of money might be put. The fact that lifespan is extended indefinitely rather than by only a couple of decades is only part of the difference that LEV makes, of course: arguably an even more important difference in terms of the benefit that SENS gives is that the whole of that life will be youthful, right up until a beneficiary mistimes the speed of an oncoming truck. The average quality of life, therefore, will rise much more than if all that was in prospect were a shift from (say) 7:1 to 9:1 in the ratio of healthy life to frail life.

Quantifying longevity escape velocity more precisely

This chapter has, I hope, closed down the remaining escape routes that might still have remained for those still seeking ways to defend a rejection of the SENS agenda. I have shown that SENS can be functionally equivalent to a way to eliminate aging completely, even though in actual therapeutic terms it will only be able to postpone aging by a finite amount at any given moment in time. I've also shown that this makes it morally just as desirable— imperative, even—as the many efforts into which a large amount of private philanthropic funding is already being injected.

I'm not complacent though: I know that people are quite ingenious when it comes to finding ways to avoid combating aging. Thus, in order to keep a few steps ahead, I have recently embarked on a collaboration with a stupendous programmer and futurist named Chris Phoenix, in which we are determining the precise degree of healthy life extension that one can expect from a given rate of progress in improving the SENS therapies. This is leading to a series of publications highlighting a variety of scenarios, but the short answer is that no wool has been pulled over your eyes above: the rate of progress we need to achieve starts out at roughly a doubling of the efficacy of the SENS therapies every 40 years and actually declines thereafter. By "doubling of efficacy" I mean a halving of the amount of damage that still cannot be repaired.

So there you have it. We will almost certainly take centuries to reach the level of control over aging that we have over the aging of vintage cars—totally comprehensive, indefinite maintenance of full function—but because longevity escape velocity is not very fast, we will probably achieve something functionally equivalent within only a few decades from now, at the point where we have therapies giving middle-aged people 30 extra years of youthful life.

I think we can call that the fountain of youth, don't you?


Notes

1. I first used the phrase "escape velocity" in print in the paper arising from the second SENS workshop—de Grey ADNJ, Baynes JW, Berd D, Heward CB, Pawelec G, Stock G. Is human aging still mysterious enough to be left only to scientists? BioEssays 2002;24(7):667-676. My first thorough description of the concept, however, didn't appear until two years later: de Grey ADNJ. Escape velocity: why the prospect of extreme human life extension matters now. PLoS Biology 2004;2(6):e187.

2. Gates disburses these funds through the Bill and Melinda Gates Foundation, http://www.gatesfoundation.org

3. Buffett's decision to donate most of his wealth to the Gates Foundation was announced in June 2006 and is the largest act of charitable giving in United States history.

© 2007 Aubrey de Grey

   
 

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Mind·X Discussion About This Article:

Aubrey De Grey
posted on 09/19/2007 5:12 PM by dog667

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Now im confused here!!!!!! did aubrey de grey just say we wont be able to live forever or what!!! he just said:WE LIVE 50 OR 60 MORE YEARS THAN TODAY . AND THE TREATMENTS THAT WE WILL USE IN THE FUTURE FOR AGING WONT BE PERFECT. What the hell???!!

Re: Aubrey De Grey
posted on 09/19/2007 7:24 PM by eldras

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well nope Aubrey says that is true for mice but not for humans.

I'm pissed that computing processing power is not the sole goal we aim at, as the achievement of A.I. will enable specific modelling of bio-systems, medical effects, climate change and everything else we want.

Re: Aubrey De Grey
posted on 09/19/2007 7:42 PM by NanoStuff

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Making anything a sole goal would be pretty damn stupid.

Re: Aubrey De Grey
posted on 09/19/2007 8:24 PM by eldras

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Everything is a sole goal, being everything!

THe effects of vitamins are astounding on longevity.

worms flies and rodents have their lives dramaticaly increased using vits and minerals.

see MC Price How to live to 200

He said this evening that there were no B3 test done on anti aging, though it's probable it has a massive life extention effect and takes 3 gammes a day.

Hew looks very young for his age after 20 years on lef stuff.

I am curious about how to effect the mitochondria.

Also the effects of gene therapy.

Superintelligence .

Re: Aubrey De Grey
posted on 09/19/2007 8:26 PM by eldras

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http://news.bbc.co.uk/player/nol/newsid_6610000/ne wsid_6612100/6612193.stm?bw=bb&mp=wm&news=1

Re: Aubrey De Grey
posted on 09/19/2007 9:01 PM by godchaser

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Gotta link for Price there e?

Much thanks.

200 hundred's a good start eh :)


Re: Aubrey De Grey
posted on 09/19/2007 9:02 PM by godchaser

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:)

I never could add good.


Re: Aubrey De Grey
posted on 09/19/2007 10:57 PM by eldras

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Google Longevity Report 98

Hi Chris

Re: Aubrey De Grey
posted on 10/10/2007 4:03 PM by dog667

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I THOUGHT OF A GREAT IDEA OF HOW WE COULD CURE AGING. OK THINK OF THIS,SERTAIN TREES LIVE FOR THOUSANDS OF YEARS AND DO NOT AGE. BUT THEY DO NEED ENERGY TO KEEP LIVING. WHAT IF WE COULD SOME HOW GET SOME OF THE GENES IN TREES THAT MAKE THEM STAY ALIVE AND MUTATE THEM IN OUR OWN HUMAN BODIES AND REPLACE OUR OLD AGING GENES WITH EDITED TREE GENES. AND THEN WE WOULD STILL EAT TO SURVIVE AND HAVE OUR NORMAL BODY FUNCTIONS BUT OUR AGING GENES WOULD BE TREE GENES.

Re: Aubrey De Grey
posted on 07/15/2008 10:11 AM by gomorrhan

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Aubrey is saying that if we live another thirty years, we'll fit into a window that will allow for rejuvenation. That rejuvenation technologies will continue to improved, probably with the same law of accelerating returns as all other forms of technology, and that this will result in indefinite lifespans for those who make it to this window, barring other forms of death.

Re: Bootstrapping our way to an ageless future
posted on 09/20/2007 10:21 AM by virtualted

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Ending Aging is a great read - I'm halfway through. I had this book preordered at Amazon and just got it earlier this week. It is a great companion to Ray and Terry's "Fantastic Voyage..." Over a year ago - registered http://www.EngineeredNegligibleSenescence.com and put up a website featuring information I had gathered about Aubrey de Grey, and other information about the anti-aging movement. The website is for the lay person - in hopes to start understanding the anti-aging movement. I believe what de Grey says that when we first publicize our success at lengthening a mouse's years significantly - the movement will gain steam, financing, and we'll be off to greatly increased human lifespans!

All the best,

Ted Stalets
http://www.DomainNesteggs.com

Re: Bootstrapping our way to an ageless future
posted on 09/23/2007 10:15 PM by dog667

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IM STILL CONFUSED!!!!!!!!!!!!!!! HE SAID THAT IT WONT BE PERFECT AND THAT THE TREATMENTS WILL ONLY MAKE US LIVE 50 OR 60 YEARS LONGER. O AND WHAT EVER HAPPENED TO NANOBOTS KEEPING US IMMORTAL?????? IM SO CONFUSED ANYMORE.

Re: Bootstrapping our way to an ageless future
posted on 09/23/2007 10:18 PM by dog667

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ELDRES WHAT DO U MEAN??,TRUE FOR MICE BUT NOT FOR HUMANS??? DO U MEAN THAT MICE WILL LIVE ONLY 50 OR 60 YEARS LONGER AND THAT HUMANS WILL LIVE LONGER??

Re: Bootstrapping our way to an ageless future
posted on 09/23/2007 11:32 PM by eldras

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The key conclusion of the logic I've set out above is that there is a threshold rate of biomedical progress that will allow us to stave off aging indefinitely, and that that rate is implausible for mice but entirely plausible for humans.

Re: Bootstrapping our way to an ageless future
posted on 09/24/2007 2:53 AM by Atomic_Piggy

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Either way, 60-70 more years is better than 40-50 more years.

Re: Bootstrapping our way to an ageless future
posted on 09/24/2007 5:39 AM by doojie

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As I understand the article, life can be expanded about 20 years, and during that twenty years, technology will advance, allowing an "escape velocity" for the aging process.

Eldras, it is precisely your faith in "modeling" various systems that bother me. The more we can model, the greater the possibility that we omit factors that will be quite useful down the road.

The development of linearity based on the phonetic alphabet caused a homogenizing effect that destroyed much variety of life that will never be regained.

Re: Bootstrapping our way to an ageless future
posted on 09/24/2007 10:56 AM by Extropia

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'IM STILL CONFUSED!!!!!!!!!!!!!!! HE SAID THAT IT WONT BE PERFECT AND THAT THE TREATMENTS WILL ONLY MAKE US LIVE 50 OR 60 YEARS LONGER. O AND WHAT EVER HAPPENED TO NANOBOTS KEEPING US IMMORTAL?????? IM SO CONFUSED ANYMORE.'

Aubrey de Grey, I think, is talking about the consequences of applying the 'Methusula mouse' treatments to human beings. These biotech treatments will slow down the cummulative damage that underlies aging, but will not be comprehensive enough to halt it completely. Therefore, using such biotech interventions we only delay senesence, rather than avoid it all together.

However, in 'Fantastic Future', Kurzweil and Grossman point out that the stuff de Grey is talking about represents the second bridge of a three-bridge approach to achieveing indefinite lifespans.

Bridge One: Eat your greens, do your exercises...do whatever is practical to maintain your health so that the much more effective senesence-slowing treatments now starting to work on mice are perfected for human use in time to be useful to you.

Bridge two: The far more effective treatments stemming from a more thorough understanding of the molecular underpinnings of aging slow down the aging process still further, hopefully enough to get you to a world where the (now) almost entirely theoretical design work of nanosurgery (as depicted in the multi-volume works of Rob Frietas) finally emerges from vapourware and enters the market.

Bridge three: Molecular nanotechnology redesigns the human animal from the subcellular level, upwards, going vastly beyond the suboptimal designs biology is limited to.

I should point out that De Grey's vision does not agree with Kurzweil and Grossman's. The latter two believe that Bridge three will be constructed only decades after bridge two is complete. However, de Grey cautions

"We will almost certainly take centuries to reach the level of control over aging that we have over the aging of vintage cars'totally comprehensive, indefinite maintenance of full function'but because longevity escape velocity is not very fast, we will probably achieve something functionally equivalent within only a few decades from now, at the point where we have therapies giving middle-aged people 30 extra years of youthful life."

I suppose Kurzweil would call that falling foul of 'inuitive linear belief', which ignores the double exponential curve technological growth. Or maybe de Grey is the realist and Messers K and G are pie-in-the-sky optimists?

Re: Bootstrapping our way to an ageless future
posted on 09/24/2007 3:48 PM by dog667

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Maybe i should tell u a little about myself. im a aa14 year old boy who cant stop thinking about dieing. the wonder if im going to live forever or if im going to die is on my mind all the time and its ruining my life. i cant concentrate in class or anything and i dont think if die then everything i will accomplish will be for nothing. PLEASE TELL ME WHAT I SHOULD DO,AND DO U THINK THAT I WILL LIVE FOREVER IF IM 14 WITH TODAYS TECKNOLOGY AND THE TECKNOLOGY OF THE FUTURE?? AND WHAT IS UR OPINION ON CRYONICS????????

Re: Bootstrapping our way to an ageless future
posted on 09/24/2007 4:23 PM by NanoStuff

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im a aa14 year old boy who cant stop thinking about dieing.

I must say I did notice some concern coming from you :)

the wonder if im going to live forever or if im going to die

You're going to die, that I can assure you of. However considering your age, I think it's very likely you will live longer than even our sun, however by that point whatever living thing there is that was derived from you won't be much at all like you. Death is progressive in this sense, the 5 year old me has all but died at this point for example. We're so worried about death yet our current self is slowly dying over time. An instant death is merely a significant jump in the process.

PLEASE TELL ME WHAT I SHOULD DO

Lose the caps for one thing :)

DO U THINK THAT I WILL LIVE FOREVER IF IM 14 WITH TODAYS TECKNOLOGY AND THE TECKNOLOGY OF THE FUTURE??

Again, no, but you're going to live a very long time without any such 'abrupt' deaths. Nobody, anywhere is going to live forever, with any technology.

ND WHAT IS UR OPINION ON CRYONICS????????

I don't care much for it. I say if you're dead, leave it be. Dead people don't care about cryonics. Although it's going to be an interesting experience for these frozen folks one day suddenly waking up in a different universe after what only felt like one night's sleep. I could certainly see offing myself to effectively jump to the future without the boring intermediate biological existence. It would sure make life a whole lot easier. But I don't think I'm going to pussy out on life like this. If we all did it, there wouldn't be anyone left to get us there.

Re: Bootstrapping our way to an ageless future
posted on 09/24/2007 6:15 PM by Extropia

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'PLEASE TELL ME WHAT I SHOULD DO,AND DO U THINK THAT I WILL LIVE FOREVER IF IM 14 WITH TODAYS TECKNOLOGY AND THE TECKNOLOGY OF THE FUTURE?? AND WHAT IS UR OPINION ON CRYONICS????????'

Really, the most sensible course of action is to take every sensible step to live a healthy lifestyle. Kurzweil and Grosmman's book 'Fantastic Voyage' is actually a pretty excellent and thorough study of the steps one can take right now to maximise a lifespan. Critics like to mock that it is the 'take 200 pills per day' diet, which is a trifle unfair given the sheer wealth of information it contains about exactly why some foods are good while others are bad, and how exercise can greatly benefit us, plus the fact the book is written to take advantage of the upcoming genomics revolution, where we will gain an ability to understand our genetic deficiencies and tailor a dietry/drugs regime to effectively combat it.

The book also contains a lot of references to the R+D being undertaken to combat the diseases of aging. The good news is that it is now widely accepted that the aging process can indeed be interrupted. The bad news is that the process by which such drugs make it onto the market is a painstakingly slow one, and one can well imagine such 'lifestyle' treatments costing enormous sums of money (regardless of how cheap they may be to actually produce) because people are known to part with mucho cash for elixers of youth.

As for cryogenics, last time I checked it cost $50,000 just to get your head frozen (if you want to preserve your body that costs $120,000).

If you have a top-class insurance policy that would cover the cost, or have tens of thousands of dollars stashed somewhere, then cryonics is certainly an option.

Re: Bootstrapping our way to an ageless future
posted on 12/16/2007 7:27 AM by Virgilic

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I don't think that one can be certain that living forever is impossible.
If I defined living as maintaining consciousness within some form of existence ( = some form of "physical" support for consciousness)it is hard, in my opinion, to be reasonably sure that eventually we will run out of such vehicles for consciousness.

I guess that you are considering the limitation in time of the universe or of its properties when you state that death is certain.

At such extremes any and all predictions are equal in value therefore I believe it to be more relevant that prediction that satisfies our desires, the optimistic ones.

Since we create technology to control the universe it is consceivable that a few billion years in the future conscious life will have the chance to create technology that will allow it to overcome the problem of the end of this universe, either by finding a solution to entropy or by creating or moving into an appropriate new universe, capable of supporting conscious life.

At least this should be the logical goal and there is no definitive proof that it will be impossible.

Re: Bootstrapping our way to an ageless future
posted on 12/16/2007 7:30 AM by PredictionBoy

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my view is not that it is impossible, but it seems not unreasonable to suggest that it will become exponentially more difficult, the more the additional age is greater than the nominal age that humans have had as a glass ceiling for millions of yrs.

Re: Bootstrapping our way to an ageless future
posted on 12/16/2007 7:32 AM by PredictionBoy

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unless we completely abandon our physical bodies and get "uploaded", which tech i still dont trust.

my thinking is still that the best option is to transplant ure living brain into a hyperadvanced droid capaple of protecting and nourishing this vital organ for as long as desired.

Re: Bootstrapping our way to an ageless future
posted on 12/16/2007 7:34 AM by PredictionBoy

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despite all the breathless confidence, i am still quite convinced that any representation of us that doesnt include our living, actual brain we were born with, will be fraught with risk, if ure intent is for you to be truly immortal.

Another way to live forever
posted on 09/24/2007 6:05 PM by Gregsi

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I read a great book where the technology is described on how we could live forever in the future when cloning technology will advance, so that we could recreate a new copy of our body with accelerated growth and then transfer our memory into it. It is a very interesting book to read, I think it can be downloaded for free at http://www.rael.org

wish you a nice reading

Re: Another way to live forever
posted on 09/24/2007 6:09 PM by NanoStuff

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Silly raelians have it all wrong. They have a noble idea, but one that won't play out.

Re: Another way to live forever
posted on 09/24/2007 6:12 PM by NanoStuff

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Point being, don't waste your time. It's really not worth reading.

Re: Another way to live forever
posted on 09/24/2007 6:23 PM by Extropia

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'I don't care much for it. I say if you're dead, leave it be.'

Rather suprised to see Nano-one make a bullshit statement such as this. It is a matter of historical fact that definitions of 'death' have had to be redefined in the face of new medical technologies. They used to think a lack of pulse was death, whereas nowadays its a sign you should start applying CPR. Lack of brain activity is currently the sure sign that you have gone beyond contemporary medical help, but the whole point of cryonics is to preserve your body and brain until subcellular repair is perfected.

Re: Another way to live forever
posted on 09/24/2007 6:23 PM by Extropia

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oops! I meant Nanostuff (wonder what happened to Nano-one?)

Re: Another way to live forever
posted on 09/24/2007 6:57 PM by NanoStuff

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No idea, but the confusion was an unnecessary burden, so I won't be crying for him :)

Anyways, as I said, I don't care much for it. I know these people can be revived, don't get me wrong, but I personally wouldn't feel comfortable burdening society with my upkeep during which period I would be contributing nothing in return. The way I see it, there's really no good reason for me to make it to the 'singularity' as such because billions of other people will on their own time. There's nothing special about me that would justify such a burden. This I feel would reflect on just about anyone else whom is 'freezable', with the exception of perhaps a select few individuals that could be expected to continue to make substantial contributions far above that of the average person even post their revival. Death as I see it should not be something that must be prevented at all cost, as you probably know from my postings.

Not that I'm absolutely against the idea, I'm in the gray area when it comes to justifiability. I don't condemn it, I just don't favor it either. My position on the matter is likely to change eventually, whether for one side or the other. Right now it's simply unclear.

Re: Another way to live forever
posted on 09/25/2007 11:51 PM by dog667

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How do you think these people can be revived??????????? even though the brain,which is what makes us us,is frozen...it still has to suffer from suffication from no air getting to causing it to be harmed. and even if our memories are saved and everything,lets say that i die in say 70 years............and i get revived from cryonics,what if i woke up and had all my memories but it wasent actually me. what if there realy is such thing as a soul??...........not a magical soul or anything,but something that actually gives us more than just awareness and conchesness. something that acctually makes us who we are. and in my opinion that i stress out very much is that the only way to achieve immortality or just physically in a state that we do not die from no cause such as aging or any other disease,unless we are in an accident,IS TO STAY ALIVE TODAY!!!!!!!! CAUSE EVEN THOUGH OUR MEMORIES ARE SAVED WE MITE BE LONG GONE. So what im getting at is that we cant for sure explain anything about this world that we live in or how we came here. and we dont know what happens after death untill we actually die,but we dont want to take that chance and see because if we do and we are dead for sure then we have 0% of coming back. we dont know if cryonics can bring us back even though i realy think we cant. BUT WHAT WE DO KNOW IS THAT IF WE MAKE THE TREATMENTS FOR IMMORTALITY WILE WE ARE ALIVE THEN WE KNOW WE CAN LIVE FOREVER BECAUSE WE DIDNT DIE. AND WE DONT HAVE TO UNDERSTAND THIS UNIVERSE TO BE HAPPY AND GET WHAT WE WANT,WE JUST NEED TO DISCOVER WHAT WE NEED TO DISCOVER......AND TO ALL YOU CHRISTIANS OUT THERE,IT REALY DOESENT MATTER IF GOD EXISTS OR NOT,PHYSICAL IMMORTALITY HAS NOTHING TO DO WITH SIN EVEN IF GOD DID EXIST BECAUSE IT IS JUST ANOTHER TECKNOLOGY ADANCEMENT IN HEALTH AND LIKE NANOSTUFF SAID..........EVEN IF WE DONT LIVE FOREVER,WE CAN STRETCH THE HUMAN LIFE SPAN SO MUCH THAT IT SEEMS LIKE IMMORTALITY. AND I WOULD JUST LIKE TO ADD THAT IF ANY SCIENTISTS ARE READING THIS,PLEASE KEEP TRYING TO MAKE US IMMORTAL BECAUSE YOU KNOW...............IF OUR LIFE WASENT ON THE LINE CAUSE OF IT THEN WE WOULDNT BE IN SUCH NEED TO HAVE IT RITE AWAY!!!!!! WERE NOT WAITING FOR HALO 3 TO COME OUT,WEREWAITING FOR LIFE TO COME OUT AND A LOT OF IT!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! !!!!!!!!!

Re: Another way to live forever
posted on 09/26/2007 12:36 AM by NanoStuff

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what if there realy is such thing as a soul??

In that case, sucks for us :)

Re: Another way to live forever
posted on 09/24/2007 7:01 PM by Gregsi

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Hey NanoStuff we don't know yet if life with cloning will or won't pay out. So I would not draw any straight conclusions. But in my opinion it is a very likely solution.

Here is what Terry Grossman wrote:
"Should we want to, and I am not sure how many of us will even want to bother, this computer replication of self may then be downloaded into a newly cloned body (a 25 year old version, of course) and the process repeated indefinitely--- Eternal Youth and True Physical Immortality."
http://www.kurzweilai.net/meme/frame.html?main=/ar ticles/art0144.html?m%3D5
I think I also remember Ray talking same solution.

This option will probably be for the people who would like to remain in human form, but there is a posibility that most would prefer the virtual way of life without a biological body.

Re: Another way to live forever
posted on 09/24/2007 7:11 PM by NanoStuff

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I can't imagine a single person not wanting to go non-biological after they've been convinced there is nothing to be lost and everything to be gained by doing so.

Perpetual cloning and wetware transfer seems like a narrow minded conclusion to be drawn from technological progress. It's analogous to suggesting we will breed bigger and faster horses never considering the automobile as an obvious and superior alternative.

Anyways, raelism is religious dogma void of scientific principles. That alone would suggest anything they have to say is a waste of time.

Re: Another way to live forever
posted on 09/24/2007 7:11 PM by NanoStuff

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Don't get me wrong, they preach science, but they vaguely understand it.

Re: Another way to live forever
posted on 10/10/2007 4:03 PM by dog667

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I THOUGHT OF A GREAT IDEA OF HOW WE COULD CURE AGING. OK THINK OF THIS,SERTAIN TREES LIVE FOR THOUSANDS OF YEARS AND DO NOT AGE. BUT THEY DO NEED ENERGY TO KEEP LIVING. WHAT IF WE COULD SOME HOW GET SOME OF THE GENES IN TREES THAT MAKE THEM STAY ALIVE AND MUTATE THEM IN OUR OWN HUMAN BODIES AND REPLACE OUR OLD AGING GENES WITH EDITED TREE GENES. AND THEN WE WOULD STILL EAT TO SURVIVE AND HAVE OUR NORMAL BODY FUNCTIONS BUT OUR AGING GENES WOULD BE TREE GENES.

Re: Another way to live forever
posted on 10/11/2007 6:15 PM by dudeunit

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Has anyone here checked out the near death studies being done? Extemely fascinating research has been done that reveals a far more fascinating experience beyond this poor mortal existence. Research done in a purely scientific way is difficult because of the nature of the phenomonen, but they have been able to do some statistical work as well as verification of some of the experiences that patients had when they were supposed to be in a coma or dead.

If the stories many people have told around the world and throughout history are to be believed, we could actually be cheating ourselves by keeping ourselves here in this plane of existence for a much longer time than was originally intended. It hardly matters though. If there is such a thing as a soul that survives after physical death that lasts forever, then what is 10,000 years to infinity? No more and no less than a day.

To the 14-year old who is afraid of dying, check out some of the research being done in this field at www.near-death.com and www.iands.com. It seems that either way, radical life-exension or actual life after death, we're all covered for eternal life.

What a fantastic age to live in!!

Re: Another way to live forever
posted on 10/11/2007 6:20 PM by martuso

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They already <a href="http://en.wikipedia.org/wiki/Ent">tried that.</a>

Re: Another way to live forever
posted on 10/11/2007 6:21 PM by martuso

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They already tried that:

http://en.wikipedia.org/wiki/Ent

Re: Bootstrapping our way to an ageless future
posted on 11/26/2007 11:30 PM by Aldune

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What he's saying is keeping people young is always going to be constant just like changing car oil.

It's only the beginning, once we have harvested the technology of the human brain and can finally transfer (save) our own memories onto our future quantum computers, we will be able to live forever.

With the power of wireless and quantum computers we can live on in more then one body and have the power to live in more then one body and still have control of our bodies. :P

Sorry I just can't think of the right words right now.

The LEV (Longevity Escape Velocity) is here.
posted on 12/22/2007 11:37 AM by raanans

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I say we are already in phase one of LEV (Longevity Escape Velocity)
Today, technology already exists for people who wish to extend their life expectancy by 20 years above the average life expectancy.

Maybe these 20 years will buy us sufficient time for phase two.

Here is how it can be done:
- Specifically designed diet. (Optimal amount of calories, + vitamin and other type of supplements)
- Physical activity.
- Mental activity.
- Getting sufficient sleep.
- Reduce stress (That can be archive by lifestyle and meditation)
- Avoid hazardous habits (Such as smoking, extreme sport, and others)

Most people, I predict, will not take these steps. Not even if it means potentially becoming immortals.

Check this Life Expectancy Calculator
http://moneycentral.msn.com/investor/calcs/n_expec t/main.asp

I discovered that I can easily add 9 years to my life expectancy just by adjusting my diet.

Re: The LEV (Longevity Escape Velocity) is here.
posted on 12/23/2007 10:25 PM by eldras

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Good post.

cripes I'm going to die in 6 years??

That didn't take account of loads of stuff and is no more than a party game.

eg I've popped loads of antioxidants for at least 15 years.

Longevity to 100 is only 4% linked to parent's ages.

Re: The LEV (Longevity Escape Velocity) is here.
posted on 12/23/2007 10:31 PM by eldras

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also:

Here is how it can be done:
- Specifically designed diet. (Optimal amount of calories, + vitamin and other type of supplements)
- Physical activity.
- Mental activity.
- Getting sufficient sleep.
- Reduce stress (That can be archive by lifestyle and meditation)
- Avoid hazardous habits (Such as smoking, extreme



I should hammer that list to my head.

I ran 6 miles 3 times a week..the result was I've hurt my bones!

There's cryonics, an also it's pretty likely future technology will develop quantum archeology and resurrect the dead. This isn't wishful ideas, there is no reason why you cant configure the patterns for people's long gone memeories based on massive probability calculations with the variables future superintelligence would be able to access.


THat sort of calculation is so vast for us to comprehend most never entertain that it is possible, because they couldn't BEGIN to think about it.

The Resurrection Covenant
posted on 12/23/2007 10:41 PM by eldras

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Eldras, it is precisely your faith in "modeling" various systems that bother me. The more we can model, the greater the possibility that we omit factors that will be quite useful down the road.


doojie

well the modelling has to be accurate!

We are just beginning to map the laws of quanta, but that will speed.

Superintelligence wil do vast computations which would even today be unimaginable in theor consequences.
You can make models now that are prett accurate


eg in archeology, they build Phillip of Maceonia's face from remains of hs skull.

They know it was a good likelness,because they have done other similar studies good enough fro relatives to recognise the victim.


But Quantum archeology will be determinist and fast enough to calculate the past and model an entire galaxy.... this MUST be true or else you would be forced to advance:




1. There is a limit to intelligence

and

2. THe universe is not determinist



And both must be true or else we certianly WILL be resurrectable by the future, whether or not we have been cryonically suspended.

Eldras, it is precisely your faith in "modeling" various systems that bother me. The more we can model, the greater the possibility that we omit factors that will be quite useful down the road.


doojie

well the modelling has to be accurate!

We are just beginning to map the laws of quanta, but that will speed.

Superintelligence wil do vast computations which would even today be unimaginable in theor consequences.
You can make models now that are prett accurate


eg in archeology, they build Phillip of Maceonia's face from remains of hs skull.

They know it was a good likelness,because they have done other similar studies good enough fro relatives to recognise the victim.


But Quantum archeology will be determinist and fast enough to calculate the past and model an entire galaxy.... this MUST be true or else you would be forced to advance


1. There is a limit to intelligence

and

2. The universe is not determinist

Re: Bootstrapping our way to an ageless future
posted on 01/06/2008 10:50 AM by francofiori2004

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Alex Chiu's immortality magnetic rings do stop aging!

WWW.ALEXCHIURINGS.COM

I am Franco Fiori, on the site yoiu can find my testimonial and pics.

It's not an hoax, it's not spamming.

Re: Bootstrapping our way to an ageless future
posted on 02/22/2008 7:38 PM by healthyguy

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I am totally enthralled in this topic and am reading the fantastic voyage right now. I also order The Baby Boomers Guide To Living Forever! I am becoming quite a fanatic about my health and I am already at the top of my range as I am a fitness professional who eats very good, and obviously exercises daily both cardio and weights, but I am wanting to learn as much as I can about the preventative nutritional approach to avoiding disease.

The journey continues.

Mike
http://www.skincarebodylotionguide.com

Re: Bootstrapping our way to an ageless future
posted on 02/22/2008 7:44 PM by PredictionBoy

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easy advice: the more body lotion, the longer the life

Re: Bootstrapping our way to an ageless future
posted on 02/22/2008 7:44 PM by PredictionBoy

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alex chew cock rings are better, immortal erections now!!

Re: Bootstrapping our way to an ageless future
posted on 02/27/2008 3:55 PM by Phaethon

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If mainstream gerontologic biomedical opinions do not bravely change with the facts in the next 15 or so years, then we will almost certainly all be dead in 60 years. It just suks to be on the cusp, doesn't it. lol

Best of luck to Aubrey and crew, my donation to SENS is in the pipeline.

Re: Bootstrapping our way to an ageless future
posted on 07/06/2008 2:26 PM by mbrito666

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Aubrey De "Dorian" Grey?? Hmmmm.........

Re: Bootstrapping our way to an ageless future
posted on 10/10/2009 8:55 AM by LleoelL

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Without reading it: This a social construct with metafysical pharmacutical paracitism of others, I vote against.

kind regards